As the saying goes, alcohol and liver cancer are standard, but recently WeChat said that research and tracking in recent years found that the cancer caused by alcohol is not limited to liver cancer, but blooms from the digestive tract to the respiratory tract to the skin. Yesterday, the reporter learned in an interview that drinking alcohol is indeed an independent factor of cancer and it can really induce a variety of cancers.
Statistics from the World Cancer Report 2014 show that 3.5% of cancers are caused by alcohol, and at the same time one in every 30 cancer deaths is caused by alcohol.
If these data are not enough to alert the good drinkers, there are still a bunch of latest experimental results. In August 2015, a prospective cohort study of 88,084 women and 47,881 men followed up for 30 years and found that the incidence of alcohol and cancer had an irrefutable linear relationship. In a similar study, researchers found that alcohol and some cancers (colorectal cancer, female breast cancer, oral cancer, throat cancer, laryngeal cancer, liver cancer, esophageal cancer) had associated risks of 1.13 (female) and 1.26 (female) male).
Other researchers have used cohort studies to verify the type of cancer associated with alcohol consumption, and found that subjects who drink heavily (more than 3 times a day) are more likely to develop five types of cancer than those who do not drink alcohol: the upper digestive tract / Respiratory cancer, lung cancer, breast cancer in women, colorectal tumors, and melanoma. The subjects with mild to moderate alcohol consumption were more susceptible to the above four tumors except lung cancer.
The specific mechanism of alcohol causing cancer varies with the type of cancer. For example, in liver cancer, alcohol first causes liver cirrhosis, while in upper gastrointestinal tumors, it is mainly because ethanol is converted into acetaldehyde in saliva, which makes B in saliva . The concentration of aldehydes is 10-100 times higher in the blood, which causes cancer of the upper digestive tract. In addition to the direct carcinogenic effects of alcohol, alcohol can also promote the large-scale generation of oxygen free radicals under the action of cytochrome P450, resulting in extensive mutation of DNA and methylation and acetylation of histones. At the same time, alcohol can reduce the concentration of retinoic acid, resulting in excessive cell proliferation and differentiation, so it is more prone to canceration. Alcohol can also affect the effects of hormones, such as increasing estradiol levels, which is one of the causes of female reproductive system cancers, such as breast ca ncer.
Wu Jianzhong, a researcher at the Jiangsu Provincial Cancer Hospital, said that the study is correct. Long-term heavy drinking does cause cancer. The few cancers that have the greatest relationship with alcohol are cancers of the digestive tract and upper respiratory tract such as liver cancer, esophageal cancer, gastric cancer, and nasopharyngeal cancer. In fact, it has an impact on other cancers. It can be said that alcohol consumption is an independent factor in the development of cancer.
So, which factor is more closely related to cancer than drinking, smoking, grilling, or eating moldy food? In this regard, Wu Jianzhong said, this is not easy to say, because the occurrence of cancer is more complicated and is the product of multiple factors.
Alcoholism induces liver cancer, which is mainly because alcoholic liver cirrhosis is induced by alcoholism all year round, which may lead to liver cancer. According to relevant literature, long-term alcoholism has a synergistic effect on the accelerated deterioration of hepatitis B into liver cancer , and has become the accomplice of hepatitis B liver cancer. So, how many of the liver cancer patients are alcoholics?
Zhou Jiahua said that from the current clinical point of view, both men and women will get liver cancer. Of course, there are more men than women. Among the patients he consults, almost 1/10 of patients with liver cancer have a habit of drinking alcohol. This does not mean that liver cancer is not much related to alcoholism. First of all, from the internal cause, you have the gene for liver cancer. If you don t, you may not have cancer because of alcohol and other causes. Second, if there is a gene for liver cancer, drinking can induce or accelerate the occurrence of liver cancer. So you dont know if you have an oncogene or stay away from these bad habits.